2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138527
    Thiol-C9-PEG4 130727-41-2 99.06%
    Thiol-C9-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-C9-PEG4
  • HY-140091
    N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) 2112737-71-8 99.78%
    N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl)
  • HY-130571
    m-PEG9-Amine 211859-73-3
    m-PEG9-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG9-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG9-Amine
  • HY-141176
    TCO-amine 1799962-26-7 99.32%
    TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-amine
  • HY-141235
    HO-PEG16-OH 6812-36-8 98.0%
    HO-PEG16-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG16-OH
  • HY-138736
    Propargyl-PEG5-Br 1287660-83-6
    Propargyl-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG5-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-Br
  • HY-130077
    Fmoc-PEG1-CH2CH2-NHS ester 1807521-05-6
    Fmoc-PEG1-CH2CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG1-CH2CH2-NHS ester
  • HY-140079
    Bis-PEG23-endo-BCN ≥98.0%
    Bis-PEG23-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-PEG23-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Bis-PEG23-endo-BCN
  • HY-140964
    Mal-PEG2-C2-Boc 1374666-31-5
    Mal-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-C2-Boc
  • HY-140841
    APN-C3-PEG4-azide 2183440-32-4
    APN-C3-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. APN-C3-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    APN-C3-PEG4-azide
  • HY-141202
    Hydroxy-PEG5-Boc 850090-09-4
    Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG5-Boc
  • HY-138507
    Desthiobiotin-PEG4-acid 2863657-56-9
    Desthiobiotin-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Desthiobiotin-PEG4-acid
  • HY-157737A
    GVSKYG-PEG2-azide hydrochloride
    GVSKYG-PEG2-azide (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    GVSKYG-PEG2-azide hydrochloride
  • HY-133190
    Bis-propargyl-PEG7 1351373-46-0 98.0%
    Bis-propargyl-PEG7 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG7 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates. Bis-propargyl-PEG7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG7
  • HY-130819
    Tos-PEG4-THP 86259-89-4
    Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).
    Tos-PEG4-THP
  • HY-140005
    Aminooxy-PEG3-acid 1807540-79-9
    Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG3-acid
  • HY-140878
    Boc-NH-PEG3-propargyl 1333880-60-6
    Boc-NH-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-NH-PEG3-propargyl
  • HY-140377
    Boc-Aminooxy-PEG4-Tos 1807539-01-0
    Boc-Aminooxy-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Aminooxy-PEG4-Tos
  • HY-143833
    Iodo-PEG7-alcohol 98.0%
    Iodo-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Iodo-PEG7-alcohol
  • HY-W014883
    1,12-Dodecanediamine 2783-17-7 99.44%
    1,12-Dodecanediamine (1,12-DD) is a reversible Maxi calcium-activated potassium channel blocker. 1,12-Dodecanediamine can reduce the single-channel current amplitude, mean channel open time, and channel open probability. 1,12-Dodecanediamine is promising for research of cell electrical signal transduction mechanism.
    1,12-Dodecanediamine
PROTAC Linkers Isoform Comparison

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